Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

Blog Article

Chronic eosinophilic Belt leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia.Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems.This is of particular significance in Sub-Saharan Africa where helminthic infections are a more prevalent cause of eosinophilia.To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian.He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly.

Good symptomatic control was achieved using hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine 3 Piece Kitchen Island Set kinase inhibitor.Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.